Bioresorbable medical implants have revolutionized clinical medicine. As opposed to permanent alternatives such as metallic implants, polymeric implants have an inherent potential to reduce the occurrence of untoward events such as inflammation by virtue of undergoing complete and controlled resorption post- implantation. While polymeric platforms demonstrate a clear potential to mitigate risk stemming from incomplete local healing, they introduce a new set of considerations to clinical safety and efficacy. Foremost among these issues is the fate of and biological response to material by-products that evolve throughout the implant degradation and erosion processes, motivating a comprehensive assessment of how material design, implant design, and deployment parameters impact implant performance.
Leave a Reply